A Comprehensive Guide to Understanding CPT Code 82310

CPT code 82310 is a specific code used in medical billing and coding to identify a particular laboratory test. This article will provide a comprehensive guide to understanding the various aspects of CPT code 82310, including its definition, application, billing and coding considerations, frequently asked questions, and a conclusion.

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What is CPT Code 82310?

CPT codes are alphanumeric codes developed by the American Medical Association (AMA) to standardize the reporting of medical procedures and services. Each CPT code represents a specific medical procedure, facilitating accurate billing and reimbursement processes.

CPT code 82310 specifically relates to the measurement of calcium levels in the blood. Calcium is an essential mineral that plays a vital role in various bodily functions, including bone health, muscle contraction, and nerve transmission.

CPT code 82310 is assigned to the laboratory test for measuring the level of calcium in a patient's blood. This test, known as the calcium assay, provides valuable information about the calcium concentration in the bloodstream. It is an essential diagnostic tool used in various medical specialties, including endocrinology, nephrology, and cardiology, to assess the patient's calcium levels and detect any abnormalities or imbalances that may indicate underlying medical conditions.

Application of CPT Code 82310:

The application of CPT code 82310 is widespread in clinical practice. Physicians and healthcare providers utilize this code to order the calcium assay and accurately document the test in the patient's medical records. The test is typically performed by collecting a blood sample from the patient and analyzing it in a laboratory setting. The results help in diagnosing and monitoring conditions such as hypercalcemia (high calcium levels), hypocalcemia (low calcium levels), kidney disorders, parathyroid gland dysfunction, and bone diseases.

Usage and Medical Applications

CPT code 82310 is commonly used in a variety of medical applications, including:

1. Diagnosing and Monitoring Bone Disorders:

 Calcium levels are closely monitored to assess bone health and identify conditions such as osteoporosis, rickets, and osteomalacia.

2. Evaluating Kidney Function: 

Abnormal calcium levels may indicate kidney disorders, such as kidney stones or impaired kidney function.

3. Assessing Parathyroid Function:

 The parathyroid glands regulate calcium levels in the body. CPT code 82310 helps evaluate parathyroid function and detect abnormalities like hyperparathyroidism or hypoparathyroidism.

4. Monitoring Certain Cancers:

 Elevated calcium levels can be associated with certain types of cancer, such as multiple myeloma and metastatic bone cancer. Monitoring calcium levels helps in disease management.

Procedure and Interpretation

The procedure for measuring calcium levels using CPT code 82310 involves a blood sample collection. The sample is then sent to a laboratory, where various methods, such as colorimetric assays or atomic absorption spectrometry, are used to measure the calcium concentration.

Interpretation of the results depends on several factors, including the patient's age, medical history, and the purpose of the test. It is essential to consult with a healthcare professional to understand the significance of the results in relation to the patient's specific condition.

Billing and Coding Considerations:

When using CPT code 82310 for billing and coding purposes, healthcare professionals need to consider several factors to ensure accurate reimbursement and proper documentation. Here are some important considerations:

1. Diagnosis Coding:

 It is crucial to select the appropriate diagnosis codes that justify the medical necessity of performing the calcium assay. Healthcare providers should use Medicare and private payer accepted diagnoses to combat denial reasons and ensure smooth reimbursement processes [1]

2. Procedural Code and DRG Information:

 Understanding the procedural code associated with CPT code 82310 helps in reporting the test accurately. Additionally, familiarizing oneself with the Diagnosis-Related Group (DRG) information, including IPPS allowable and length of stay, is essential for inpatient facility revenue management [1]

3. Anesthesia Code Crosswalk:

 In certain cases, the calcium assay may be performed under anesthesia. Healthcare professionals can simplify anesthesia code crosswalk and payment calculations by utilizing specialized tools like Anesthesia Coder [1]

4. HCPCS Level II Codes:

 It is worth exploring HCPCS Level II codes and their definitions to ensure accurate coding and documentation for any related services or supplies [1]

Frequently Asked Questions (FAQs):

1. What are the common symptoms of calcium imbalances?

   - Symptoms of hypercalcemia (high calcium levels) may include fatigue, excessive thirst, frequent urination, nausea, and constipation.

   - Symptoms of hypocalcemia (low calcium levels) may include muscle cramps, tingling sensations, numbness, and confusion.

2. How is the calcium assay performed?

   - The calcium assay involves collecting a blood sample from the patient, usually from a vein in the arm. The sample is then sent to a laboratory, where it undergoes analysis to determine the calcium concentration.

3. Are there any specific preparations required for the calcium assay?

   - In most cases, no special preparations are needed for the calcium assay. However, healthcare providers may advise patients to avoid certain medications or dietary supplements that could potentially interfere with the test results.

4. Can calcium imbalances be treated?

   - Yes, depending on the underlying cause, calcium imbalances can be treated. Treatment may involve lifestyle modifications, medication, or surgical interventions, as determined by the healthcare provider.

Q5: What are the normal calcium levels in the blood?

A5: The normal calcium range in adults is typically between 8.5 to 10.2 milligrams per deciliter (mg/dL).

Q6: Are there any preparation requirements for the test?

A6: Fasting is not necessary for a calcium blood test. However, certain medications or supplements may interfere with the results. It is advisable to inform the healthcare provider about any medications or supplements being taken.

Q7: Can calcium levels be affected by other factors?

A7: Yes, factors such as vitamin D deficiency, certain medications, thyroid disorders, and kidney problems can affect calcium levels.

Q8: How often should calcium levels be monitored?

A8: The frequency of monitoring calcium levels depends on the patient's medical condition and the healthcare provider's recommendations. In some cases, regular monitoring may be required, while in others, periodic tests may be sufficient.


CPT code 82310 plays a significant role in the accurate reporting, billing, and coding of the calcium assay. Understanding the application of this code, along with proper billing and coding considerations, is crucial for healthcare professionals to ensure seamless reimbursement processes and comprehensive patient care. By following the guidelines outlined in this article, healthcare providers can effectively utilize CPT code 82310 in their practice, leading to improved diagnosis and management of calcium-related disorders.

Reference :

[1] CPT® Code 82310 - Chemistry Procedures - Codify by AAPC