Comprehensive Guide to CPT Codes 82306, 82652, and Vitamin D Testing

Vitamin D plays a crucial role in maintaining overall health and is associated with various conditions and diseases. To ensure accurate testing and appropriate insurance coverage, it is essential to understand the relevant CPT codes. This article aims to provide a comprehensive guide to CPT codes 82306 and 82652, their significance in vitamin D testing, and the latest coverage determinations by UnitedHealthcare.

1. Understanding Vitamin D Testing:

Vitamin D testing measures the levels of 25-hydroxyvitamin D in the blood, which is the most accurate indicator of an individual's vitamin D status. This test helps healthcare providers assess vitamin D deficiency, monitor treatment effectiveness, and determine appropriate supplementation. Proper coding and billing for vitamin D testing are vital for accurate reimbursement and ensuring patient access to necessary care.

2. CPT Code 82306: 

CPT code 82306 is used for the quantification of 25-hydroxyvitamin D, including both 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3. This code is widely recognized and utilized in laboratory settings to measure total vitamin D levels. It plays a crucial role in identifying deficiencies and guiding treatment plans for patients.

3. CPT Code 82652:

CPT code 82652 is specifically used for the quantification of 25-hydroxyvitamin D3. It focuses solely on measuring the active form of vitamin D in the blood. This code allows for a more accurate assessment of vitamin D status, as it measures the metabolically active component responsible for the majority of vitamin D's biological effects.

4. Coverage Determinations by UnitedHealthcare:

Effective from March 1, 2022, UnitedHealthcare has implemented new coverage determinations for vitamin D testing [1]. Under these determinations, UnitedHealthcare will only cover vitamin D screening with specific CPT codes, including 82306, 82652, or 0038U, for plan members with corresponding diagnosis codes. It is essential for healthcare providers to familiarize themselves with these policies to ensure proper reimbursement and patient care.

5. Frequently Asked Questions (FAQs):

Q1: What are the common symptoms of vitamin D deficiency?

A: Common symptoms of vitamin D deficiency include fatigue, muscle weakness, bone pain, frequent infections, and low mood.

Q2: Are there any specific risk factors for vitamin D deficiency?

A: Yes, certain factors can increase the risk of vitamin D deficiency, such as limited sun exposure, darker skin pigmentation, obesity, older age, and certain medical conditions.

Q3: How is vitamin D deficiency treated?

A: Vitamin D deficiency is commonly treated through supplementation with vitamin D3 and lifestyle modifications, such as increased sun exposure and dietary changes.

6. Conclusion:

Accurate coding and understanding of CPT codes 82306 and 82652 are essential for healthcare providers to ensure proper reimbursement and effective management of vitamin D deficiencies. By staying informed about the latest coverage determinations, such as those implemented by UnitedHealthcare, providers can navigate the billing process efficiently. Regular vitamin D testing can contribute to the overall health and well-being of patients, aiding in the prevention and management of various conditions.

Remember, proper utilization of CPT codes ensures accurate reimbursement and quality patient care. Stay up to date with the latest coding guidelines and insurance policies to provide the best possible service to your patients.


1. UnitedHealthcare Provider - New coverage determinations for Vitamin D testing. Retrieved from